Process for the preparation of 1,3-oxazine-4-ones

Details Process for the preparation of 1,3-oxazine-4-ones Process for the preparation of 1,3-oxazine-4-ones

1984-09-17

1985-06-04

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

2602433, 544 88, 544 96, C07D26502

Patent

active

045215995

ABSTRACT:
This invention relates to the use of 6-aryluracils as antiinflammatory and antiarthritic agents and also to both novel intermediates and novel processes for the preparation of selected 6-aryluracils.

REFERENCES:
patent: 2758994 (1956-08-01), Lacey
patent: 4171429 (1979-10-01), Watanabe et al.
Johnson et al., "Researches on Pyrimidines LXXIV, Synthesis of 4-Phenylcytosine," J. Am. Chem. Soc., vol. 37, pp. 378-383, (1915).
Gershon et al. "Pyrimidines. III, Some 6-Substituted Di- and Trichloropyrimidines," J. Med. Chem., vol. 6, pp. 87-89, (Jan. 1963).
Lacey, "Derivatives of Acetoacetic Acid Parts V and VI", J. Chem. Soc., pp. 839-844, (1954).
Moszew et al., "New Type of Addition of Aromatic Isocyanates to Benzoylacetamide, 1,6-Diaryl Derivatives of Uracil," Zesz. Nauk. Univ. Jagiellon, Pr. Chem., 1969, No. 14, pp. 31-45, C.A., 72:12242e.
Hannon et al., Tetrahedron Letters, 21, 1105, (1980).
Clark et al., "Heterocyclic Studies, Part XIX, Some 6-(Substituted phenyl)-uracil and -thiouracil Derivatives", J. Chem. Soc. (C)., pp. 1945-1948, (1971).
Clark et al., "Heterocyclic Studies, Part XXVII, Mass Spectra of 6-(meta- and para- Substituted -phenyl)-uracil and -thiouracil Derivatives", J. Chem. Soc. Perkin II, pp. 233-237, (1972).
Senda et al., "Pyrimidine Derivatives and Related Compounds, 15, Synthesis and Analgetic and Antiinflammatory Activities of 1,3-Substituted 5-Amino-6-Methyluracil Derivatives." J. Med. Chem., vol. 15, No. 5, pp. 471-476, (1972).
Derwent, Abstract 62348T-BC.
Ahmed et al., "Purines, Pyrimidines, and Imidazoles, Part XLIV, Synthesis of Some Dihydro-1,3-oxazine Derivatives and Related Substituted Uracils," J.C.S. Perkin I, pp. 1969-1975, (1976).
U.S. application Ser. No. 303,694.
Yogo et al., "Pyrimidine Derivatives and Related Compounds, 38, (1), Synthesis of 1,3-Oxazine-2,4-diones and Their Reaction with Necleophiles, Ring Transformation of 1,3-Oxazines to Pyrimidines," J. Heterocyclic Chem., 18, pp. 1095-1100, (Oct. 1981).
Glenn et al., Life Sciences, 5: 619, (1966).
C. A. Winter, E. A. Risley, G. W. Nuss, Proc. Soc. Exp. Biol. Med., 111, 544, (1962).
Finney, D. J., (1964), Statistical Method in Biological Assay, Hafner, N.Y.
Boissona, Adv. Org. Chem., 3, 159, (1963).
Windholz et al., Tetrahydron Lett., 8, 2555, (1967).

Affiliated with

Also associated with

Rating

Process for the preparation of 1,3-oxazine-4-ones does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of 1,3-oxazine-4-ones, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of 1,3-oxazine-4-ones will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-829985