Method for producing analgesia in mammals

Details Method for producing analgesia in mammals Method for producing analgesia in mammals

1988-11-14

1990-05-01

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

A61K 3154

Patent

active

049218530

ABSTRACT:
A method for administering xylazine to a mammal in which xylazine is injected in the subarachnoid space or in the caudal epidural space of the mammal. This method produces analgesia and less extraspinal side effects such as sedation, ataxia and cardiovascular depression.

REFERENCES:
W. V. Lumb and E. W. Jones, "Spinal Anesthesia" in Veterinary Anesthesia, 1984, pp. 400-402.
T. L. Yaksh, "Pharmacology of Spinal Adrenergic Systems which Modulate Spinal Nociceptive Processing", Pharmacology Biochemistry & Behavior, vol. 22, pp. 845-858, 1985.
Fleetwood-Walker et al., "An A.sub.2 Receptor Mediates the Selective Inhibition by Noradrenaline . . . ", Brain Research, vol. 334, pp. 243-254, 1985.
D. W. Coombs, et al., "Intrathecal Morphine Tolerance: Use of Intrathecal Clonidine . . . ", Anesthesiology, vol. 62, pp. 358-363, 1985.
D. B. Brunson et al., "Comparative Analgesia of Xylazine, Xylazine/Morphine, Xylazine/Butorphanol . . . ", Am. Journ. Vet. Res., vol. 48, pp. 1087-1091, 1987.
W. W. Muir, et al., "Effect of Xylazine on Indices of Myocardial Contractility in the Dog", Am. Journ. Vet. Res., vol. 38, pp. 931-934, 1977.
F. B. McCashin, et al., "Evaluation of Xylazine as a Sedative and Preanesthetic Agent in Horses", Am. Journ. Vet. Res., vol. 36, pp. 1421-1429, 1975.

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