Biliary acid derivatives, processes for the preparation thereof

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

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552549, 552550, 552551, A61K 3156, C07J 100

Patent

active

049218484

ABSTRACT:
Compounds of formula I ##STR1## wherein: R.sub.1 is hydrogen or hydroxy, and the methyl and hydroxy groups at 6- and 7-positions respectively can be either in .alpha. or .beta. configuration, are useful in human therapy. Compounds I are prepared by methylation of the corresponding appropriately protected 7-keto-derivatives.

REFERENCES:
patent: 2615902 (1950-10-01), Hirschmann et al.
patent: 2938031 (1960-04-01), Bible et al.
patent: 2966499 (1960-12-01), Hinkley et al.
patent: 3591687 (1971-07-01), Bray
patent: 4172076 (1979-10-01), Hirsch et al.

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