Substituted .alpha.-amino acids having selected acidic moieties

Details Substituted .alpha.-amino acids having selected acidic moieties Substituted .alpha.-amino acids having selected acidic moieties

1990-04-23

1993-08-24

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514538, 514539, 514540, 562426, 562432, 562441, 562442, 562444, 562445, 562449, A01N 3710, C07C22900

Patent

active

052389588

ABSTRACT:
The present invention is novel substituted .alpha.-amino acids, pharmaceutical compositions, methods of use, and preparations therefore having utility for treating disorders which benefit from blockade of aspartate and glutamate receptors.

REFERENCES:
patent: 2500019 (1950-03-01), Bergworth
patent: 4065572 (1977-12-01), Atkinson et al.
patent: 4657899 (1987-04-01), Rzeszotarski et al.
patent: 4740615 (1988-04-01), McManus et al.
patent: 4746653 (1988-05-01), Hutchinson et al.
patent: 4761405 (1988-08-01), Rzeszotarski et al.
Scrip #1067 Jan. 13, 1986 (p. 22).
Neurology and Neurobiology, vol. 24 (19-26 "Excitatory Amino Acid Transmission" J. C. Watkins, et al 1987.
Tetrahedron 33:2715-7 (1977) D. Ben-Ishai, et al "The Synthesis of p-Substituted D,L-Phenylglycines by the Amidoalkylation of Benzylchloride and N-Benzyl-benzamide".

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