N-acyl-tetrahydroisoquinolines as inhibitors of acyl-coenzyme A:

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514253, 514307, 544215, 544333, 544405, 546145, 546146, 546147, A61K 3147, A61K 31495, A61K 31505, A61K 3153

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active

052389359

ABSTRACT:
N-acyltetrahydroisoquinolines including novel compounds of the formula ##STR1## wherein R.sup.1 is a C10-C25 alkyl chain; a substituted C10-C25 alkyl chain; an interrupted C10-C25 alkyl chain; a substituted interrupted C10-C25 alkyl chain; diphenylamino; di-(R.sup.2 -substituted phenyl)amino; di-(heteroaryl)amino; di-(R.sup.2 -substituted heteroaryl)amino; diphenylmethyl; or di-(R.sup.2 -substituted phenyl)methyl;

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Stenlake, et al., Eur. J. Med. Chem.-Chim. Ther., 9(3), 239-242 (1974); Chem. Abstr. 82(9): 57976v.

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