Mixed immunoglobulins for detection of rheumatoid factors

Details Mixed immunoglobulins for detection of rheumatoid factors Mixed immunoglobulins for detection of rheumatoid factors

1991-10-07

1993-08-24

Nucker, Christine M.

Chemistry: analytical and immunological testing

For preexisting immune complex or auto-immune disease

Rheumatoid factors

435 71, 435 75, 435 792, 435 793, 435 794, 435 795, 436501, 436503, 436506, G01N 33564, G01N 3353, G01N 33566, C12Q 100

Patent

active

052388514

ABSTRACT:
Assays are provided for detecting the existence of active rheumatoid arthritis by detecting rheumatoid factor as a blood component which cross-links human IgG with sheep IgG. Particularly, an enzyme labelled assay is provided using biotin-avidin to link the enzyme to the immunoglobulin.

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M. Wilchek, et al., Immunology Today, vol. 5, No. 2, pp. 39-43 (1984).
J. T. Barrett, Textbook of Immunology, 3rd Ed., C. V. Mosby Company, St. Louis, Mo., pp. 428-430 (1978).

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