Methods and materials for treatment of disease states involving

Details Methods and materials for treatment of disease states involving Methods and materials for treatment of disease states involving

1982-05-17

1985-06-04

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 88, A61K 39165

Patent

active

045214050

ABSTRACT:
In animals including humans, the symptoms of non-anaphylactic disease states wherein the disease victim's humoral and/or cell-mediated immunological response is involved in disease pathology are alleviated upon administration of compositions comprising mixtures of histamine and one or more immunogenic substances participative in the humoral or cell-mediated pathogenic response. In preferred embodiments, the compositions are administered in essentially minute, "neutralizing" doses. Illustratively, significant relief of symptoms of multiple sclerosis is achieved through parenteral (e.g., subcutaneous of sublingual) administration of mixtures of histamine and measles virus immunogen. For a majority of patients, from about 8.8.times.10.sup.-6 to 5.5.times.10.sup.-3 mg of histamine phosphate will provide an effective quantity of histamine to a unit dose of the mixture. Likewise, a unit dose of the mixture will contain from about 2.times.10.sup.-3 to about 4.times.10.sup.-4 times the prescribed vaccination dose of a killed, attenuated measles virus vaccine strain. As another example, rheumatoid arthritis symptoms are alleviated by administration of histamine admixed with an immunoglobulin G immunogen which is provocative of in vivo rheumatoid factor production.
Other immune disorders (e.g., chronic pain and herpes simplex type II infections) are effectively treated with admixtures of histamine and appropriate immunogen(s).

REFERENCES:
Chemical Abstracts, vol. 66, Abstract No. 9402a, 1967.
Permin, H. et al., Allergy, vol. 33, pp. 15-23, 1978.
European Journal of Chemical Investigation, vol. 10, No. 2, Apr. 1980, Abstract No. 81.

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