Process for the preparation of isoquinoline derivatives

Details Process for the preparation of isoquinoline derivatives Process for the preparation of isoquinoline derivatives

1989-02-22

1992-01-07

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 70, C07D 4004, C07D21364, C07D26306

Patent

active

050793632

ABSTRACT:
The subject of the present invention is a process for the preparation of isoquinoline derivatives in four steps wherein use is made as synthetic intermediates of organo-lithium compounds or related compounds.

REFERENCES:
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Morrison and Boyd, Organic Chemistry (Boston, Allen and Bacon, 1979) pp. 992-993.
Canadian Journal of Chemistry, 59, (1981), Robins et al., pp. 2601-2607.
Journal of Organic Chemistry, 47, (1982), Meyers et al., pp. 2633-2637.
Journal of Organic Chemistry, 48, (1983), Saulnier et al., pp. 2690-2695.
Chem. Ber., 117, (1984), Vorbruggen et al., pp. 1523-1541.
Journal of Organic Chemistry, vol. 45, 1980, pp. 4508-4511, American Chemical Society, Washington, U.S.; G. R. Newkome et al., "Pyrolysis of alkyl 2- or 6-alkoxynicotinates. An unexpected reaction".
Tetrahedron Letters, No. 47, 1978, pp. 4639-4642, Pergamon Press Ltd, Oxford, GB; G. R. Newkome et al: "Restricted N,N-dimethylnicotinamides".

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