Microgel drug delivery system

Details Microgel drug delivery system Microgel drug delivery system

1990-04-12

1992-01-07

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424487, 424 7831, 523105, 523409, 523412, 523522, 524522, 526320, A61K 3174

Patent

active

050789945

ABSTRACT:
A copolymer microparticle is presented which is derived from at least about 5 weight percent of free carboxylic acid group-containing vinyl monomers, monomers which have a poly(alkylene oxide) appended thereto, oleophilic monomers and other nonionic hydrophilic monomers. Microgels containing these copolymers having a median water swollen diameter of about 0.01 to about 1.0 micrometer are disclosed. Pharmaceutical and diagnostic compositions are disclosed comprising a therapeutic or diagnostic agent and microgels comprising a copolymer derived from at least about 5 weight percent of non-esterified carboxylic acid group-containing vinyl monomers, oleophilic monomers and other nonionic hydrophilic monomers, with the proviso that when the median water swollen diameter of the microgels is 0.1 micrometer or greater, at least 5 weight percent of the monomers have a poly(alkylene oxide) appended thereto. Diagnostic and therapeutic methods are also disclosed wherein the microgels are substantially protein non-adsorbent and substantially refractory to phagocytosis.

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Poste et al., Biotechnology (Dec. 1983), pp. 869-877.
Couvreur et al., Polymeric Nanoparticles and Microspheres, CRC Press, Boca Raton, Fla., pp. 27-93.
Andrade et al., Adv. Poly. Sci. 79:1-63 (1986).
Nagaoka et al., Polymers as Biomaterials Plenum Press, pp. 361-374 (1984).
Journal of Pharmaceutical Sciences, vol. 78, No. 6, Jun. 1989, "Blood Clearance and Organ Distribution of Intravenously Administered Polymethacrylic Nanoparticles in Mice".

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