Hemostyptic and tissue adhesive

Details Hemostyptic and tissue adhesive Hemostyptic and tissue adhesive

1996-06-10

1999-03-16

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, 530381, 530384, A61K 3800, C07K 1400

Patent

active

058830782

ABSTRACT:
A stable tissue adhesive is described which comprises fibrinogen and an activator or pro-activator of prothrombin, wherein its content of prothrombin present in blood is less than 5 units/g fibrinogen. This tissue adhesive can be present as a liquid or dry preparation and can optionally be applied to a biologically degradable water-soluble support.

REFERENCES:
patent: 4427650 (1984-01-01), Stroetmann
patent: 4442655 (1984-04-01), Stroetmann
patent: 4453939 (1984-06-01), Zimmerman et al.
patent: 4948724 (1990-08-01), Yin
patent: 5407671 (1995-04-01), Heimburger et al.
Rosing et al., Thombosis and Haemostatis, 65(5): 627-630 (1991).
Olson et al., Biochimica et Biophysica Acta, 557: 9-23 (1979).
Quick, J. Biol. Chemist, 109: 73-74.
Caplus Abstract No. (1991): 30152 JP 02167234.

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