Methods and apparatus for the conditioning of cartilage replacem

Details Methods and apparatus for the conditioning of cartilage replacem Methods and apparatus for the conditioning of cartilage replacem

1998-04-07

1999-03-16

Redding, David A.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Solid support and method of culturing cells on said solid...

4352841, 4352865, 600 36, 73790, 73807, 73818, 73843, 73846, 73847, C07C 0000, C12M 300

Patent

active

058829296

ABSTRACT:
Apparatus and methods are disclosed for maturing a biopolymer tissue construct in vitro prior to use as a replacement construct in vivo as, for example, a graft, implant, or prosthesis. The tissue is seeded with specific cells, exposed to a maturation fluid, such as a synovial-like fluid containing hyaluronic acid, and subjected to selected conditioning and maturation forces, which can include frictional forces, shear forces, and compressive pressure. The tissue is mounted on a first support element and a second surface applies a selected force to the tissue. This maturation process occurs within a maturation chamber. The resultant matured replacement tissue construct is intended to provide a replacement tissue that is more readily integrable in vivo to produce a more durable and functional replacement tissue.

REFERENCES:
patent: 5521087 (1996-05-01), Lee et al.
patent: 5700688 (1997-12-01), Lee et al.
patent: 5792603 (1998-08-01), Dunkelman et al.
D. Huang et al., "Mechanisms and Dynamics of Mechanical Strengthening in Ligament-Equivalent Fibroblast-Populated Collagen Matrices," Annals of Biomedical Engineering, vol. 21, pp. 289-305 (1993).
E. Bell, Tissue Engineering: Current Perspectives, Birkhauser, Boston, 1993 .

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