INHA crystals and three dimensional structure

Details INHA crystals and three dimensional structure INHA crystals and three dimensional structure

1996-08-21

1999-03-16

Wax, Robert A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving oxidoreductase

435 26, 435189, 536 232, 536 237, C12Q 126

Patent

active

058828788

ABSTRACT:
This invention relates to InhA enzyme crystals and to the use of said crystals to determine the three dimensional structure of InhA enzyme. This invention is further directed to a method of treating M. tuberculosis infection utilizing compounds which bind to InhA enzyme.

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Canetti, Am. Rev. Respir. Dis., vol. 92, p. 687 (1965).
Banerjee et al. (1994) Science, 263, "inhA, a Gene Encoding a Target for Isoniazid and Ethionamide in Mycobacterium tuberculosis", pp. 227-230.
Dessen et al. (1995) Science, 267, "Crystal Structure and function of the Isoniazid Target of Mycobacterium tuberculosis ", pp. 1638-1641.
McPherson (1976) Meth. Biochem. Anal., 23, "The Growth and Preliminary Investigation of Protein and Nucleic Acid Crystals for X-Ray Diffraction Analysis", pp. 249-345.
Delucas et al. (1987) Trends Biochem. Technol., 5, "New Directions in Prottein Crystal Growth", pp. 188-193.
Giegeet al. (1989) Trends Biochem. Technol., 7, "Crystallogenesis of Proteins", pp. 277-282.

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