Electrolytic transdermal delivery of polypeptides

Details Electrolytic transdermal delivery of polypeptides Electrolytic transdermal delivery of polypeptides

1987-02-10

1989-11-07

Rosenbaum, C. Fred

Surgery

Means for introducing or removing material from body for...

Infrared, visible light, ultraviolet, x-ray or electrical...

A61N 130

Patent

active

048788929

ABSTRACT:
The invention comprises in combination:
(a) a polypeptide having from about three to about 20 peptide units in aqueous solution or suspension, and
(b) an electrolytic device for transdermal transport of the polypeptide to the bloodstrem of the patient.
It may be useful to enhance the transdermal delivery of the polypeptide by adding an aqueous cosolute/cosolvent with negative Setschenow constants.
The electrolytic device preferably comprises a hydrophilic reservoir containing a supply of the aqueous polypeptide solution or suspension, an electric battery, two extended contacts, and optionally a semipermeable membrane between the reservoir and the patient's skin.
Representative polypeptides include oxytocin, angiotensin I, II, and III, substance P, vasopressin, lypressin, desmopressin, leuprolide acetate, antripeptin, and the like.

REFERENCES:
patent: 4459226 (1984-07-01), Grimes et al.
patent: 4557723 (1985-12-01), Sibalis
patent: 4624665 (1988-11-01), Nuwayser
patent: 4702732 (1987-10-01), Powers et al.
patent: 4704282 (1987-11-01), Campbell et al.
patent: 4710497 (1987-12-01), Heller et al.
patent: 4713244 (1987-12-01), Baum et al.
patent: 4725439 (1988-02-01), Campbell et al.
patent: 4752285 (1988-06-01), Petelenz

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