Method for the enhancement of lymphocyte activity against opport

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

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514654, A61K 31135

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active

059555084

ABSTRACT:
The invention relates to the treatment of an immunocompromised human, e.g., an AIDS or HIV positive patient, for the enhancement of lymphocyte activity against opportunistic microbial pathogens or the treatment of any human for the enhancement of lymphocyte activity against tumors using a lymphocyte-activity-enhancing amount of dextrofenfluramine or a pharmaceutically-acceptable acid addition salt thereof.

REFERENCES:
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patent: 5502080 (1996-03-01), Hitzig
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Clancy, J., Jr. et al.. 1993. Interactions between serotonin and the immune system: an overview. In: P.M. Vanhoutte et al., (Eds.), Serotonin From Cell Biology to Pharmacology and Therapeutics. Kluwer: London, pp. 353-357.
Lorens, S.A., et al.. 1993. The stimulatory effects of d-fenfluramine (d-FEN) on blood and spleen immune functions in the Fischer 344 rat are age and sex dependent. In: P.M. Vanhoutte et al. (Eds.), Serotonin From Cell Biology to Pharmacology and Therapeutics. Kluwer: London, pp. 337-343.
Petrovic, L.M., et al. 1991. Subchronic d-Fenfluramine treatment enhances the immunological competence of old female Fischer 344 rats. In: J.R. Fozard and P.R. Saxena (Eds.), Serotonin: Molecular Biology, Receptors and Functional Effects. Birkhauser Verlag: Basel, pp. 389-397.
Clancy, J., Jr., et al. 1991. Effects of subchronic d-fenfluramine on splenic immune functions in young and old male and female Fischer 344 rats. Inter. J. Immunopharm. 13:1203-1212.
Clancy, J., Jr. and S. A. Lorens. 1996. Subchronic and chronic exposure to d-fenfluramine dose-dependently enhances splenic immune functions in young and old male Fischer-344 rats. Behav. Brain Res. 73:355-358.
Matthews, H.L., et al. 1996b. Effect of d-fenfluramine on the local immune response to the opportunistic microbial pathogen Candida albicans. Behav. Brain Res. 73:369-374.
The Merck Index, Eleventh Edition, entry 3920, p. 624.
Wurtman, USP 4,649,161, Abstract.

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