Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-11-21
1999-09-21
Jarvis, William R. A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 31445
Patent
active
059554770
ABSTRACT:
The optically pure (-) isomer of cisapride is useful for the treatment of dyspepsia and such other conditions as may be related to the activity of (-) cisapride as a prokinetic agent, such as gastroparesis, constipation, post-operative ileus, and intestinal pseudo-obstruction, without the concomitant liability of adverse effects associated with the racemic mixture of cisapride. The (-) isomer of cisapride also exhibits longer duration of action than does racemic cisapride and is useful for treatment of disorders of the central nervous system.
REFERENCES:
patent: 4962115 (1990-10-01), Van Daele
patent: 5057525 (1991-10-01), Van Daele
patent: 5114714 (1992-05-01), Young et al.
patent: 5114715 (1992-05-01), Young et al.
patent: 5137896 (1992-08-01), Van Daele
Porsius, A.J., et al., "Farmacotoets 6A," Farmacotherapie, 129:9:214-217 (1994).
Schiavi, G.B., et al., "Identification of Serotonin 5-HT.sub.4 Recognition Sites in the Porcine Caudate Nucleus by Radioligand Binding," Neuropharmacology, 33:543-549 (1994).
Krejs, G.J., "Serotonine intestinale, une cible therapeutique," Med. Chir. Dig., 22:7:415-416 (1993).
Zuccato, E., et al., "The Effects of S(-) and R(+) Sulpiride, Metoclopramide, Cisapride and Domperidone on the Small Intestine Suggest DA.sub.2 -Receptors are Involved in the Control of Small Intestinal Transit Time in Rats," Pharmacological Research, 26:2:179-185 (1992).
Gladziwa, U., et al., "Pharmacokinetics and pharmacodynamics of cisapride in patients undergoing hemodialysis," Clinical Pharmacology, 50:6:673-681 (1991).
Gullikson, G.W., et al., "Relationship of Serotonin-3 receptor Antagonist Activity to Gastric Emptying and Motor-Stimulating Actions of Prokinetic Drugs in Dogs," Journal of Pharmacology and Experimental Therapeutics, 258(1):103-110 (1991).
Frazer, A., et al., "Subtypes of Receptors for Serotonin," Annual Rev. of Pharmacology and Toxicology, 30:307-348 (1990).
Schapira, M., et al., "The Current Status of Gastric Prokinetic Drugs," Acta Gastroenterolog. Belg. LIII:446-457 (1990).
Clarke D.E., et al., "The 5-HT.sub.3 Receptor: Naughty, but Nice," Trends in Pharmacological Sciences, 10:385-386 (1989).
Craig & Clark, "5-Hydroxtryptamine and Cholinergic Mechanisms in Guinea-pig Ileum," Brit. J. Pharmacol., 96:247 (1989).
Dumuis, A., et al., "The Gastrointestinal Prokinetic Benzamide Derivatives are Agontist at the Non-Classical 5-HT Receptor (5-HT.sub.4) Positively Coupled to Adenylate Cyclase in Neurons," N.S. Arch. Pharmacol., 340:403-410 (1989).
Jamali, F., "Enantioselective Aspects of Drug Action and Disposition: Therapeutic Pitfalls," Journal of Pharmaceutical Sciences,78(9):695-715 (1989).
Nemeth et al., Chemical Abstracts, vol. 11, No. 19, Abs. No. 167161a (1989).
Nemeth, P.R. and Gullikson, G.W., "Gastrointestinal Motility Stimulating Drugs and 5-HT Receptors on Myenteric Neurons," European Journal of Pharmacology, 166:387-391 (1989).
Scrip's New Product Review No. 32 Cisapride, PJB Publications Ltd. (Apr. 1989).
Barnes, N.M., et al., "Identification of 5-HT.sub.3 Recognition Sites in the Ferret Area Postrema," J. Pharm. Pharmacol., 40:586-588 (1988).
Decktor, D.L., et al., "Effect of Metoclopramide, Bethanechol and the Cholecystokinin Receptor Antagonist, L-364, 718, on Gastric Emptying in the Rat," Eur. J. Pharmacol., 147-313-316 (1988).
Lauwers, W., et al., "Identification of a Biliary Metabolite of Cisapride," Biomedical and Environmental Mass Spectrometry, 15:323-328 (1988).
Meuldermans, W., et al., "Excretion and Biotransformation of Cisapride in Dogs and Humans After Oral Administration," Drug Metabolism and Disposition, 16:3:403-419 (1988).
Meuldermans, W., et al., "Excretion and Biotransformation of Cisapride in Rats After Oral Administration," Drug Metabolism and Disposition, 16:3:410-419 (1988).
Van Peer, A., et al., "Clinical Pharmacokinetics of Cisapride," Progress in the Treatment of Gastrointestinal Motility Disorders: The Role of Cisapride, Proceedings of a Symposium in Frankfurt Excerpta Medica, pp. 23-29 (1988).
Barone et al., "Bioavailability of Three Oral Dosage Forms of Cisapride, a Gastrointestinal Stimulant Agent," Clinical Pharmacy, 6:640-645 (1987).
Costall, B., et al., "Emesis Induced by Cisplatin in the Ferret as a Model for the Detection of Anti-Emetic Drugs," Neuropharmacology, 26:1321-1326 (1987).
Stacher et al., "Effects of Oral Cisapride on Interdigestive Jejunal Motor Activity, Psychomotor Function, and Side-Effect Profile in Healthy Man," Digestive Disease and Sciences, 32(11):1223-1230 (1987).
Van Daele, G.H.P., et al., "Synthesis of Cisapride, a Gastrointestinal Stimulant Derived From Cis-4-Amino-3-Methoxypiperidine," Drug Development Research, 8:225-232 (1986).
Fernandez & Massingham, "Peripheral Receptor Populations Involved in the Regulation of Gastrointestinal Motility and the Pharmacological Actions of Meoclopramide-like Drugs," Life Sci., 36:1-14 (1985).
Schuurkes, J.A.J., et al., "Motor-Stimulating Properties of Cisapride on Isolated Gastrointestinal Preparations of the Guinea Pig," J. Pharmacol. Exp. Ther., 234:775-783 (1985).
Williams & Burks, "Cisapride Increases Gastric Emptying Without Affecting Small or Large Bowel Transit," Proc. West. Pharmacol. Soc., 28:47-50 (1985).
Milo, R., "Non-Cholinergic, Non-antidopaminergic Treatment of Chronic Digestive Symptoms Suggestive Of A Motility Disorder: A Two-Step Pilot Evaluation of Cisapride," Curr. Therapeutic Research, 36:5:1053-1062 (1984).
Reyntjens, A., et al., "Clinical Pharmacological Evidence For Cisapride's Lack of Antidopaminergic or Direct Cholinergic Properties," Current Therapeutic Research, 36:5:1045-1052 (1984).
Lavrijsen, K., et al., "The Role of CYP3A4 in the In-Vitro Metabolism of Cisapride in Human Liver Microsomes and In-Vitro and In Vivo Interactions of Cisapride with Co-Administered Drugs," Dept. of Pharmacokinetics and Drug Metabolism, Janssen Research Foundation, 1995.
Gray Nancy M.
Young James W.
Jarvis William R. A.
Sepracor Inc.
LandOfFree
Methods for treating gastrointestinal motility dysfunction using does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for treating gastrointestinal motility dysfunction using, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for treating gastrointestinal motility dysfunction using will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-80553