Thiadiazole or oxadiazole analogs of fenamic acids containing su

Details Thiadiazole or oxadiazole analogs of fenamic acids containing su Thiadiazole or oxadiazole analogs of fenamic acids containing su

1991-12-17

1993-05-18

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514364, 548143, 548144, 548136, 548138, C07D271113, C07D285125, A61K 3141

Patent

active

052121895

ABSTRACT:
The present invention is a novel compound which is a thiadiazole or oxadiazole analog of a fenamic acid having a substituted hydroxamate side chain and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and methods of use thereof. The invention compounds are now found to have activity as inhibitors of one or both of cyclooxygenase and 5-lipoxygenase providing treatment of conditions advantageously affected by such inhibition including inflammation, arthritis, pain, fever, and the like. Thus, the present invention is also a pharmaceutical composition or method of use thereof.

REFERENCES:
patent: 3413313 (1968-11-01), Scherrer
patent: 4092430 (1978-05-01), Sallmann et al.
patent: 4981865 (1991-01-01), Belliotti
patent: 5017604 (1991-05-01), Beliotti et al.
Derwent Abstract 87-130305/19 for NL 8602-610-A & DE 3636413.

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