Derivatives of L-proline, their preparation and their biological

Details Derivatives of L-proline, their preparation and their biological Derivatives of L-proline, their preparation and their biological

1988-11-03

1993-05-18

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530331, C07K 508, A61K 3702

Patent

active

052121585

ABSTRACT:
The L-proline derivatives of the invention correspond to the Formula I: ##STR1## in which R.sub.1 corresponds to the Formula II: ##STR2## in which R is a carbonyl group, an acyl group --Y--CO-- or an oxy-acyl group --O--Y--CO--, Y being an alkyl or an alkenyl chain, Z being one or more hydrogen atoms, or one or more substituents chosen from among halogen atoms, CF.sub.3, alkyl or alkoxy groups and an alkylenedioxy group in the case of two neighbouring substituents,

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Pitt et al: "Effect of hypoxia and hypercapnia on ACE activity in the cerebral microcirculation of anesthetized dogs", Am. J. Physiol. 250 (Heart Circ. Physiol. 19) H806-H814, 1986.
Venkatachalapathi et al: "X-Pro Peptides: Synthesis and Solution Conformation of Benzyloxycarbonyl-(Aib-Pro),-Methyl Ester, Evidence for a Novel Helical Structure", Biopolymers, vol. 20, 1137-1145, (1981).
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