Polypeptide agents for blocking the human allergic response

Details Polypeptide agents for blocking the human allergic response Polypeptide agents for blocking the human allergic response

1976-01-27

1979-10-16

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352

Patent

active

041712994

ABSTRACT:
A group of relatively low molecular weight polypeptides having from 3 to 10 amino acids block the allergic response. These "blocking" polypeptides have amino acid sequences corresponding to amino acid sequences appearing in the 2nd, 3rd and 4th domains of the epsilon chain of IgE. Specific active "blocking" polypeptides are disclosed and the synthesis and use thereof are described.

REFERENCES:
J. M. Stewart and J. D. Young, "Solid Phase Peptide Synthesis," Freeman and Co., San Francisco, 1969, pp. 1-18.
Bennich et al., Adv. in Immunol., 13, 1-55 (1971).
Ishizaka et al., "Specific Receptors of Antibodies, Antigens and Cells," 3rd Internat. Convoc. on Immunol., Buffalo, 1972, Karger, Basel, Switz., 1973, pp. 69-79.

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