Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1979-04-09
1983-12-13
Coughlan, Jr., Paul M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
544 22, A61K 31545, C07D50146
Patent
active
044204787
ABSTRACT:
Novel syn isomers of oximes of 3-azidomethyl-7-amino-thiazolyl-cephalosporanic acids of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms, unsaturated alkyl of 2 to 4 carbon atoms, benzoyl and --(CH.sub.2).sub.n --R.sub.1, n is an integer from 1 to 4, R.sub.1 is selected from the group consisting of NH.sub.2 and --COOA' and A' and A are selected from the group consisting of hydrogen, alkali metal, alkaline earth metal, magnesium, --NH.sub.4, an easily cleavable ester group and a non-toxic, pharmaceutically acceptable organic amine and their non-toxic, pharmaceutically acceptable acid addition salts having antibiotic activity and a novel process and novel intermediates for their preparation.
REFERENCES:
patent: 4076936 (1978-02-01), Laundon
patent: 4098888 (1978-07-01), Ochiai et al.
Bucourt et al., "C. R. Acad. Sc. Paris" May 1977, p. 1847ff.
Numata et al., The Journal of Antibiotics, vol. 31, No. 12, pp. 1262-1271, Dec. 1978.
Heymes Rene
Lutz Andre
Coughlan, Jr. Paul M.
Roussel Uclaf
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