Substituted benzonitriles having antiviral activity

Details Substituted benzonitriles having antiviral activity Substituted benzonitriles having antiviral activity

1980-01-25

1981-03-03

Torrence, Dolph H.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

260465E, 260465F, 260465G, 260465R, A61K 31275, C07C12160, C07C12175, C07C12178

Patent

active

042541441

ABSTRACT:
Substituted benzonitriles are disclosed having the formula ##STR1## wherein X represents O or S; R.sub.1 represents bromo, chloro, fluoro, phenoxy, loweralkylthio, loweralkylsulfinyl, loweralkylsulfonyl, loweralkylaminosulfonyl, diloweralkylaminosulfonyl or benzoyl; and R.sub.2 represents hydrogen, bromo, chloro or fluoro with the proviso that R.sub.2 is hydrogen when R.sub.1 is a substituent other than bromo, chloro or fluoro. The compounds of the invention exhibit antiviral activity. Methods of use based on the antiviral activity of the compounds are also disclosed, as well as compositions which comprise a carrier in combination with a suitable antiviral active compound.

REFERENCES:
patent: 3711506 (1973-01-01), Wagner et al.
patent: 3766238 (1973-10-01), Rohr et al.
patent: 3776961 (1973-12-01), Theisson
patent: 3813444 (1974-05-01), Abe et al.
patent: 3821312 (1974-06-01), Abe et al.
patent: 4005141 (1977-01-01), Moore et al.
patent: 4039588 (1977-08-01), Wilson et al.
patent: 4086255 (1978-04-01), Moore et al.
patent: 4106925 (1978-08-01), Rohr et al.
patent: 4164412 (1979-08-01), Moore et al.

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