Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1995-06-07
1999-09-21
Elliott, George C.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
4352351, 435325, 536 2372, C12N 510, C12N 1548, C12N 700
Patent
active
059553316
ABSTRACT:
Packaging cell lines useful for the generation of helper-free recombinant retroviruses with amphotropic or ecotropic host ranges, methods of constructing such packaging cell lines and methods of using the recombinant retroviruses to introduce DNA of interest into eukaryotic cells, both in vitro and in vivo.
REFERENCES:
patent: 4650764 (1987-03-01), Temin et al.
patent: 5278056 (1994-01-01), Bank et al.
patent: 5449614 (1995-09-01), Danos et al.
Danos and Mulligen, 1988, "Expression of retroviral transacting functions from complementary crippled genomes:a system for helper free packaging of retroviral vectors," J. Cellular Biochemistry Supplement 12B:Abstract H106 p. 172.
Josef Ban et al., 1989, "Bovine Leukaemia Virus Packaging Cell Line for Retrovirus-mediated Gene Transfer," J. gen. Virol. 70: 1987-1993.
Olivier Danos and Richard C. Mulligan, 1988, "Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges," Proc. Natl. Acad. Sci. U.S.A. 85: 6460-6464.
J. Sorge et al., 1984, "Amphotropic Retrovirus Vector System for Human Cell Gene Transfer" Mol. and Cell. Biol. 4:1730-1737.
R.D. Cone and R.C. Mulligan, 1984, "High-efficiency gene transfer into mammalian cells: Generation of helper-free recombinant retrovirus with broad mammalian host range" Proc. Natl. Acad. Sci. U.S.A. 81: 6349-6353.
R. Mann and D. Baltimore, 1985 J. Virol 54:401-407.
A.D. Miller and C. Buttimore, 1985, "Factors Involved in Productin of Helper Virus-free Retrovirus Vectors" Somat. Cell Genet., 12:175-183.
A.D. Miller et al., 1986, "Redesign of Retrovirus Packaging Cell Lines to Avoid Recombination Leading to Helper Virus Production" Mol. and Cell. Biol. 6:2895-2902.
M.A. Bender et al., 1987, "Evidence that the Packaging Signal of Moloney Murine Leukemia Virus Extends in the gag Region" J. Virol 61:1639-1646.
R.A. Bosselmann et al., 1987, "Replication-Defective Chimeric Helper Provirus and Factors Affecting Generation of Competent Virus: Expression of Moloney Murine Leukemia Virus Structural Genes via the Metallothionein Promoter" Mol. and Cell. Biol. 7:1797-1806.
O. Danos and R.C. Mulligan, 1988, UCLA Symposium.
D. Markowitz et al., 1988, A Safe Packaging Line for Gene Transfer: Separating Viral Genes on Two Different Plasmids J. Virol 62:1120-1124.
O. Danos and R.C. Mulligan, 1988, RNA Tumor Viruses, Cold Spring Harbor Sumpos. May 17-22.
D. Markowitz et al., 1988, Virology 167:400-406.
S.K. Chattopadhyay et al., 1981, "Genomes of Murine Leukemia Viruses Isolated from Wild Mice," J. Virology 39:777-791.
R. Mann et al., 1985, "Construction of a Retrovirus Packaging Mutant and Its Use to Produce Helper-Free Defective Retrovirus" Cell 33:153-159.
S. Watanbe and H. Temin, 1983, "Construction of a Helper Cell Line for Avian Reticuloendotheliosis Virus Cloning Vectors" Mol. and Cell. Biol. 3:2241-2249.
Small, J. and G. Scangos et al., 1983, "Recombination During Gene Transfer into mouse Cells Can Restore the Function of deleted Genes," Science 219:174-176.
S.A. Rosenburg et al., 1990, New Engl. J. Med. 323:570-578.
Hurford, Jr. R. et al., 1995, "Gene therapy of metastatic cancer by in vivo retroviral gene targeting," Nat. Genet. 10(4):430-435.
Gilboa, E. "Retrovirus vectos and their uses in molecular biology," Bioessays 5(6):252-257 (1986).
Lim, B. et al. "Retrovirus-mediated gene transfer of human adenosine deaminase: expression of functional enzyme in murine hematopoietic stem cells in vivo," Molec. Cell. Biol. 7(10):3459-3465 (1987).
Wilson, J. et al. "Correction of the genetic defect in hepatocytes from the Watanabe heritable hyperlipidemic rabbit," Proc. of the Natl. Acad. of Sci. 85:4421-4425 (1988).
Israel et al. "Retroviral-mediated transfer and amplification of a functional human factor VIII gene," Blood 75(5):1074-1080 (1990).
Morgenstern et al. "Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line," Nucleic Acids Research 18(12):3587-3596 (1990).
Danos Olivier
Mulligan Richard C.
Brusca John S.
Elliott George C.
Whitehead Institute for Biomedical Research
LandOfFree
Recombinant retroviruses with amphotropic and ecotropic host ran does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Recombinant retroviruses with amphotropic and ecotropic host ran, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Recombinant retroviruses with amphotropic and ecotropic host ran will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-79479