Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1981-10-21
1984-09-18
Love, Ethel G.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
2601125R, 536 177, 424180, A61K 3700, A61K 3170, C07C10352, C07H 1520
Patent
active
044723792
ABSTRACT:
Novel nitrosourea derivatives are provided which possess a high level of inhibitory activity against leukemia and tumors and which are therefore useful for pharmaceutical purposes. The compounds have the structure represented by formula (I): ##STR1## wherein R.sub.0 represents --OH or --OC.sub.m H.sub.2m+1 where m is an integer of 1 to 3 and one of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 represents ##STR2## where X is ##STR3## or an alkylene group of 1 to 3 carbon atoms, n is an integer of 1 to 3 and Y is the group on the .alpha.-carbon atom of an .alpha.-amino acid and each of the remaining three represents --OH; or wherein R.sub.0 represents ##STR4## and R.sub.1, R.sub.2, R.sub.3 and R.sub.4 each represent --OH; or by formula (II): ##STR5## wherein X and n have the same meanings as above; and p is an integer of 1 to 5.
REFERENCES:
patent: 4057684 (1977-11-01), Kimura et al.
patent: 4180655 (1979-12-01), Suami et al.
patent: 4182757 (1980-01-01), Tsujihara et al.
patent: 4237273 (1980-12-01), Horvath et al.
patent: 4367239 (1983-01-01), Bregnedal et al.
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