Topically active steroidal anti-inflammatory agents

Details Topically active steroidal anti-inflammatory agents Topically active steroidal anti-inflammatory agents

1987-12-04

1990-03-20

Lipovsky, Joseph A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514181, 514182, 26039747, 540 62, A61K 3156, C07J 100, C07J 7100

Patent

active

049101927

ABSTRACT:
Introduction of a C-12 substituent and especially a .beta. C-12 substituent into glucocorticoids improves their usefulness as topical antiinflammatories by increasing their topical activity relative to their systemic activity, thus reducing systemic side effects such as adrenal suppression.

REFERENCES:
patent: 2787623 (1957-04-01), Bebert
patent: 3053834 (1962-09-01), Fried
patent: 3169978 (1965-02-01), Diassi et al.
patent: 3316282 (1967-04-01), Ivashkiv
patent: 3405127 (1968-10-01), Shaw
Taub et al. "Cortical Steroids Substituted at C-12" J Am Chem Soc, vol. 79, 452 (1979).
Remingtons Pharmaceutical Sciences 15th Ed 1975.

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