Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-03-28
1994-06-07
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514274, 544302, 544314, A61K 31505, C07D23910
Patent
active
053189728
ABSTRACT:
A pyrimidine nucleoside derivative and pharmaceutically acceptable salt thereof specified by the presence of ethyl group or isopropyl group at 5-position of the pyrimidine ring and the presence of a (substituted) phenylthio or a (substituted) benzyl group at 6-position of the pyrimidine ring is provided. The pyrimidine nucleoside derivative and pharmaceutically acceptable salt thereof show a markedly higher anti-retroviral activity than conventional analogous compounds and have a relatively low toxicity against the host cells, and therefore, are useful as an active ingredient of antiviral agent.
REFERENCES:
patent: 4613604 (1986-09-01), Chu et al.
patent: 4868187 (1989-09-01), Ogilvie
Chu et al, J. Hetero cyclic chemistry 23, 289-319, 1986.
Drabikowaka et al, Chemical Abstract, 107, 1987 #129717w.
Baba Masanori
De Clercq Erik D. A.
Miyasaka Tadashi
Tanaka Hiromichi
Ubasawa Masaru
Conlin David G.
Gupta Y. N.
Mitsubishi Kasei Corporation
Shah Mukund J.
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