Method for treatment of arterial stenosis

Details Method for treatment of arterial stenosis Method for treatment of arterial stenosis

1994-10-17

1996-05-28

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3152

Patent

active

055211917

ABSTRACT:
A method is disclosed for treatment of arterial stenosis which comprises administering to a warm-blooded mammal following balloon angioplasty a small but effective amount of zaprinast sufficient to inhibit intimal hyperplasia in said mammal.

REFERENCES:
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McMahon, et al., J. Pharmacol. Exp. Therap. 251, 1000-1005 (1989).
Buchholz, et al., Fed. Am. Soc. Exp. Biol. J3, A1186 (1989).
Lugnier, et al., Am. J. Physiol. 262, H654-H660 (1992).
Burns, Chem. Absts. 117: 22314 (1992).
Wilkins et al. J. Clin. Invest. 85, 1274-1279 (1990).

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