Pseudopeptide bradykinin receptor antagonists

Details Pseudopeptide bradykinin receptor antagonists Pseudopeptide bradykinin receptor antagonists

1992-10-08

1996-05-28

Chan, Christina Y.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530329, 530314, A61K 3808

Patent

active

055211585

ABSTRACT:
The invention relates to peptides of up to 10 amino acids that are synthesized by substituting at least one of the bradykinin amino acids found in positions 2, 3, 4 and 5 of the bradykinin peptide with a fatty acid amine. The modified bradykinin peptides produced confer increased resistance to enzymatic degradation and/or tissue specificity. The invention also relates to pharmaceutical preparations and processes of treatments using the modified bradykinin peptides.

REFERENCES:
patent: 4242329 (1980-12-01), Claeson et al.
patent: 4693993 (1987-09-01), Stewart et al.
patent: 4801613 (1989-01-01), Stewart et al.
patent: 5385889 (1995-01-01), Kyle
Journal of Medicine Chemistry, 1991, vol. 34, No. 8, pp. 2649-2653.

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