Process for the preparation of N-acylated 2-chloro-5-aminomethyl

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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546262, 546337, 546194, 5462697, 5462711, 5462714, 5462721, 5462764, 5462747, 5462754, 5462791, 5462804, 5462847, C07D21356

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055809839

ABSTRACT:
2-Chloro-5-(N-acyl-aminomethyl)pyridines can be prepared by hydrogenation of 2-chloro-5-cyanopyridine with hydrogen in an acylating agent using a hydrogenation catalyst.

REFERENCES:
patent: 5300650 (1994-04-01), Nabata
patent: 5382671 (1995-01-01), Diehr
patent: 5453506 (1995-09-01), Diehr
English translation of DE 42 22 152, (Jan. 13, 1994).
E. M uller, Mehtoden der Organischen Chemie (Houben-Weyl), 4, vol. XI/1, pp. 556-557, Georg Thieme Verlag, Stuttgart, (1957).
Patent Abstracts of Japan, vol. 18, No. 75, abstract of JP-05-286936, (1994).

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