Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1994-01-21
1996-12-03
Ceperley, Mary E.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 75, 436520, 436532, 436822, G01N 33547, G01N 33567, G01N 33577
Patent
active
055807429
ABSTRACT:
For the detection of proteins containing phosphorylated tyrosine the sample of a body fluid is incubated with at least two receptors R.sub.1 and R.sub.2 whereby a change in signal is produced by binding of at least the receptors R.sub.1 and R.sub.2 with the substance to be detected in the sample solution and in which in each case one of the two receptors contains an antibody or its derivative capable of specifically binding to the protein to be detected and the other receptor contains an antibody or its derivative capable of specifically binding to phosphorylated tyrosine and the signal change caused by the binding is determined in the sample.
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M. Torosian, Surgery, Gynecology and Obstetrics, vol. 166 (1988) 567-579. The clinical usefulness and limitations of tumor markers.
Y. Durocher et al., Cancer Research, 49, 4818-4823 (1989). Tyrosine Protein Kinase Activity of Human Hyperplastic Prostate and Carcinoma Cell Lines PC3 and DU145.
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Bodenm uller Heinz
Dessauer Andreas
Boehringer Mannheim GmbH
Ceperley Mary E.
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