Primycin salts

Details Primycin salts Primycin salts

1988-10-31

1991-06-11

Peselev, Elli

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 65, A61K 3170, C07H 1504

Patent

active

050232428

ABSTRACT:
The invention relates to salts of primycin formed with an organic acid--preferably a C.sub.1-16 aliphatic carboxylic acid, a halogenated carboxylic acid, an aliphatic dicarboxylic acid, an aromatic carboxylic acid, a substituted aromatic carboxylic acid or an organic sulfonic acid--or an inorganic acid--preferably a hydrohalogenic acid. There is further on provided a process for the preparation of new primycin salts which comprises reacting a suspension of primycin sulfate formed with an aliphatic alcohol containing 1-4 carbon atoms with a barium salt. The new primycin salts of the present invention possess excellent antibiotic properties.

REFERENCES:
patent: 3244590 (1966-04-01), Schaffner et al.
patent: 4035568 (1977-07-01), Schaffner et al.
patent: 4404189 (1983-09-01), Kulcvar et al.
Progress in Medicinal Chemistry, vol. 14, Ellis, G. P. et al., pp. 105-115 (Elsevier/North Holland 1977).
Merck Index, 10th Edition, Compound 7652, 1983.

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