Biphenyl-5,5'-bis-alkanoic acid derivatives, their production an

Details Biphenyl-5,5'-bis-alkanoic acid derivatives, their production an Biphenyl-5,5'-bis-alkanoic acid derivatives, their production an

1991-08-08

1992-08-04

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

549427, 560 59, C07C 5940, A01N 3710

Patent

active

051360900

ABSTRACT:
An aldose reductase inhibitor, comprising a compound of the formula ##STR1## or a pharmaceutically acceptable salt thereof as the effective component, in which R denotes an alkyl of C.sub.1-12, ##STR2## wherein X.sub.1 and X.sub.2 are same or different and are hydrogen or halogen, cyclohexylmethyl, cyclohexyl, tetra-hydro-2H-pyran-1-yl-methyl, carboxy-lower alkyl or cyclo-lower alkyl and n is 2 or 3. These compounds exhibit a superior aldose reductase inhibiting activity with simultaneous high stability, and are for use in the prevention and therapy of diabetic complications.

REFERENCES:
patent: 4749571 (1988-06-01), Yaginuma et al.
"Dealkylation of Esters and Cleavage of Alcoholic Carbon-oxygen Bond of Lactones with Aluminium Halide-thiol System", Tetrahedron Letters No. 52, by M. Node et al., pp. 5211-5214.
"Synthesis of Bitetralonyl and Bianthronyl Derivatives from Biphenyl Derivatives", Journal of Indian Chemical Society, vol. 42, No. 2, 1965, by K. P. Mathai et al., pp. 86-91.

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