Pharmaceutical compositions comprising phosphatidyl carnitine fo

Details Pharmaceutical compositions comprising phosphatidyl carnitine fo Pharmaceutical compositions comprising phosphatidyl carnitine fo

1990-05-03

1992-08-04

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514 78, A61K 31685

Patent

active

051359219

ABSTRACT:
We describe the use of phospholipidic carnitine derivatives of general formula ##STR1## in their racemic or optically active form, wherein R.sub.1 and R.sub.2, equal or different, are radicals of linear or branched, saturated or monoor poly-unsaturated, aliphatic acids with 1 to 20 C for the preparation of pharmaceutical compositions having an activity as reproductive agent of the nerve fibers in the therapy of human pathologies associated with neuronal damages, more particularly in the therapy of peripheral neuropathies, of cerebrovascular diseases, of cerebral level traumas and of chronic neurodegenerative diseases.

REFERENCES:
patent: 4343816 (1982-08-01), Cavazza
patent: 4346107 (1982-08-01), Cavazza et al.
patent: 4439438 (1984-03-01), Cavazza
Hintze, V et al. Lipids 10(1): 20-24 (1975).
Curti, D et al. Biological Psychiatry (1985).
Tempesta, JL Int. J. Clin. Pharm. Res. 3(4): 295-306 (1983).

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