Thyroid hormone receptor

Details Thyroid hormone receptor Thyroid hormone receptor

1990-10-24

1992-09-01

Lacey, David L.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

5303879, 530395, 53038822, 5303891, 435 691, 536 27, C07K 1300, C07K 1528

Patent

active

051440075

ABSTRACT:
This invention provides a substantially purified thyroid hormone receptor, termed herbA-T, defined by its complete amino acid sequence deduced from its cDNA and the binding of thyroid hormone by the protein translated from the mRNA corresponding to the cDNA. The cDNA, the protein produced from it, and antibodies reactive therewith are also provided.

REFERENCES:
Ichikawa et al. Chem. Abstracts 105:91787n, Sep. 15, 1986.
Sap et al. Nature 324:635-640, Dec. 18, 1986.
Benbrook et al. Science 238:788-791 Nov. 6, 1987.
Spurr et al. EMBO Journal 3(1) pp. 159-163, 1984.
Hudson & Hay "Practical Immunology" Blackwell Press pp. 303-326 (1980).
Davis et al. "Microbiology" Harper & Row, Publishers pp. 338-341.
Weinberger et al., The c-erg-A gene encodes a thyroid hormone receptor, Nature 324:641-646 (1986).
Thompson et al., Identification of a Novel Thyroid Hormone Receptor Expressed in the Mammalian Central Nervous System, Science 237:1610-1613 (1987).

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