5-Alkyl-1,6-naphthyridin-2(1H)-ones and cardiotonic use thereof

Details 5-Alkyl-1,6-naphthyridin-2(1H)-ones and cardiotonic use thereof 5-Alkyl-1,6-naphthyridin-2(1H)-ones and cardiotonic use thereof

1983-06-09

1985-05-14

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546122, 546123, C07D47104, A61K 3144

Patent

active

045171904

ABSTRACT:
1-R"-3-Q-4-R'-5-R-1,6-naphthyridin-2(1H)-ones (I) or salts thereof, where R is lower-alkyl, R' is hydrogen or methyl, R" is hydrogen or lower-alkyl, and Q is hydrogen, hydroxy, amino, cyano, carbamyl, carboxy or aminocarbamyl, are useful as cardiotonic agents (I, Q is hydrogen, hydroxy, amino, cyano or carbamyl) and/or intermediates therefor (I, Q is carboxy, aminocarbamyl, hydrogen, amino, cyano or carbamyl). Also shown are 3-Q'-4-R'-5-(RCO)-6-[2-(di-lower-alkylamino)ethenyl]-2(1H)-pyridinones (II) or salts thereof, where R and R' are as above and Q' is hydrogen or cyano, which are useful as cardiotonics (II, Q' is hydrogen) and/or intermediates (II, Q' is cyano or hydrogen). Processes for preparing the compounds of formulas I and II are shown.

REFERENCES:
Chemical Abstracts 72, 12,615d (1970).
Ogata et al., [Chem. Pharm. Bull. 20, 2264 (1972)].
Hawes et al., [J. Med. Chem. 16, 849 (1973)].
Hawes et al., [J. Heterocycl. Chem. 11, 151 (1974)].
Moller et al., [Ann. 612, 153 (1957)].

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