Process of forming 2-(2-bromo-2-nitroethenyl)-furan

Details Process of forming 2-(2-bromo-2-nitroethenyl)-furan Process of forming 2-(2-bromo-2-nitroethenyl)-furan

1989-09-13

1990-10-23

Raymond, Richard

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D30738

Patent

active

049653776

ABSTRACT:
2-(2-bromo-2-nitroethenyl)-furan can be used as an antimicrobial in broad spectrum of uses. A novel process for preparing 2-(2-bromo-2-nitroethenyl)-furan has been found in which furfural is reacted with bromonitromethane using a primary amine or primary amine salt as a catalytic agent to produce an intermediate product which is dehydrated in the presence of acid to the desired product. An antimicrobial composition comprising 2-(2-bromo-2-nitroethenyl)-furan and a carrier is also disclosed.

REFERENCES:
patent: 2335384 (1943-11-01), Bousquet et al.
patent: 2632776 (1953-03-01), Slagh
Nazarova and Potemkin, "Synthesis of Some Furylnitroolefins with Potential Biological Activity", Potemkin Khim. Farm. Zh., vol. 6, 1972, pp. 629-632.
Gruntfest, et al., "Physiochemical Properties and Reactivities of Furylnitroolefins", Zhurnal Organicheskoi Khimii, vol. 8, 1972, pp. 405-411.
Nazarova, "Concerning B-Nitrovinyl-5-Substituted Furans", Zhur. Cebshcksi Khim, vol. 24, 1954, pp. 589-592.
Kamalov, et al., "Study of the Formation and Properties of a Series of Furyl-Substituted Ethylenes", Doklady Akademij Nauk SSSR, vol. 232, 1977, pp. 68-71.
Sturdik, et al., "Reaction of Vinylfurans with Sulfhydryl and Amino Groups", Biochemical Pharmacology, vol. 28, 1979, pp. 2525-2530.
Sturdik, et al., "Biochemically Important Reactions of 2-Furylethylenes, Reactions with Low-Molecular Thiols", Coll. Czech. Chem. Comm., vol. 47, 1982, pp. 1523-1529.
Balaz, et al., "Biochemically Important Reactions of 2-Furylethylenes, Characterization of the Reactivity Towards Thiols", Coll. Czech. Chem. Comm., vol. 47, 1982, pp. 1659-1666.
Gruntfest, et al., "Dipole Moments and Reactivities in the Furylnitro Olefin Series", Zhurnal Organicheskoi Khimii, vol. 7, 1971, pp. 1057-1062.
Kada, et al., "Preparation of 5-X-2-(2-Nitrovinyl)-furans and Their Reactions with Nucleophiles", Coll. Czech. Comm., vol. 49, 1984, pp. 2496-2501.
Latif et al., "Biologically Polyactive Compounds, Nitrovinylfurans, Dihydrofuro[2,3-b]benzo[e]dioxins, and Hydroxyphenyl Esters of 2-Furoic Acid of Inhibiting Properties Towards Bacteria, Fungi, Yeast, and Aquatic Snails", Journal f. prakt. Chemie, vol. 315 1973, pp. 419-426.
Schales et al., "Arylnitroalkenes: A New Group of Antibacterial Agents" J. AM. Chem. Soc. vol. 74 1952, pp. 4486-4490.
Gruntfest et al, Chemical Abstracts, vol. 76(1972) 139829q.
Nazarova et al, Chemical Abstracts, vol. 78(1973) 43166m.

Affiliated with

Also associated with

Rating

Process of forming 2-(2-bromo-2-nitroethenyl)-furan does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process of forming 2-(2-bromo-2-nitroethenyl)-furan, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process of forming 2-(2-bromo-2-nitroethenyl)-furan will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-767904