Method for preparing indole carboxylic acid derivatives

Details Method for preparing indole carboxylic acid derivatives Method for preparing indole carboxylic acid derivatives

1990-03-07

1990-10-23

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548430, 548508, 546 94, 544 35, 544101, C07D20918, C07D47106

Patent

active

049653695

ABSTRACT:
A method of preparing indole carboxylic acid derivatives from aniline derivatives is described which can be carried out in a single reaction vessel without any isolation of intermediate products. The method involes reacting an aniline derivative with a soluble nitrite in an acid medium, reducing the resulting nitrosamine by treating the acidic nitrosamine containing reaction solution with zinc in the presence of sufficient acid, optionally with addition of additional acid and/or a solvent such as a lower alcohol, reacting the resulting hydrazine derivative containing solution with a lower alkyl ester of pyruvic acid to obtain a corresponding hydrazone which cyclizes to yield an indole carboxylic acid ester, and if desired, hydrolyzing the ester to obtain the corresponding carboxylic acid.

REFERENCES:
patent: 4736043 (1988-04-01), Michel et al.

Affiliated with

Also associated with

Rating

Method for preparing indole carboxylic acid derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for preparing indole carboxylic acid derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for preparing indole carboxylic acid derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-767868