Tetrahydroisoquinoline compounds

Details Tetrahydroisoquinoline compounds Tetrahydroisoquinoline compounds

1989-08-23

1990-10-23

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546144, 546146, 546150, C07D21716

Patent

active

049653601

ABSTRACT:
Novel 4-amino-6,7-dimethoxy-2-(6,7-disubstituted-1,2,3,4-tetrahydroisoquinol-2-y l)quinoline compounds have been prepared, including their pharmaceutically acceptable salts and various novel key intermediates therefor. These compounds are useful in therapy as anti-arrhythmic agents and therefore, are of value in the treatment of various cardiac arrhythmias. Preferred compounds include 4-amino-6,7-dimethoxy-2-(6-hydroxy-7-methoxy-1,2,3,4-tetrahydroisoquinol-2 -yl)quinoline and 4-amino-6,7-dimethoxy-2-(7-hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinol-2 -yl)-quinoline. Methods for preparing these compounds from known starting materials are provided.

REFERENCES:
patent: 3855228 (1974-12-01), Bailey
patent: 4656174 (1987-04-01), Campbell et al.
patent: 4686228 (1987-08-01), Campbell et al.
patent: 4758568 (1988-07-01), Campbell et al.
Campbell, et al., "Chemical Abstracts", vol. 101, 1984, col. 101:7051e.
Campbell, et al., "Chemical Abstracts", vol. 102, 1985, col. 105:45882e.

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