Penicillanic acid derivative

Details Penicillanic acid derivative Penicillanic acid derivative

1983-04-11

1985-05-14

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D49900, A61K 31425

Patent

active

045171262

ABSTRACT:
6-.beta.-Substituted penicillanic acids and derivatives thereof as useful enhancers of the effectiveness of several .beta.-lactam antibiotics against many .beta.-lactamase producing bacteria, and 6-.beta.-substituted penicillanic acid derivatives wherein the carboxy group is protected by a conventional penicillin carboxy protecting group as useful intermediates leading to said synergistic agents. A process for converting 6,6-disubstituted penicillanic acid derivatives to the corresponding 6-.beta.-substituted penicillanic acid congeners.

REFERENCES:
patent: 4180506 (1979-12-01), Pratt
patent: 4203992 (1980-05-01), Gordon et al.
Loosemore and Pratt, Journal of Organic Chemistry, 43, 3611, (1978).
Roets, Vlietinck and Vanderhaeghe, Journal of the Chemical Society, (London), Perkin I, 704, (1976).
Knott-Hunziker, Orlek, Sammes and Waley, Biochemical Journal, 177, 365, (1979).

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