Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Patent
1988-08-30
1992-09-01
Rosen, Sam
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
435105, 435 72, 435100, 536117, 536124, C12P 1926
Patent
active
051438313
ABSTRACT:
A method for preparing optically pure N-containing sugars is disclosed wherein an optically impure chiral aldehyde acceptor is enzymatically condensed with dihydroxyacetone phosphate or dihydroxyacetone with a catalytic amount of inorganic arsenate in the presence of an aldolase to form an N-containing sugar.
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Wong, C-H., Mazenod, F. P., Whitesides, G. M. "Chemical and Enzymatic Syntheses of 6-Deoxyhexoses. Conversion to 2,5-dimethyl-4-hydroxy-2,3-dihydrofuran-3-one (Furaneol) and Analoges." J. Org. Chem. 48 (1983) 3493.
Wong, C-H., Whitesides, G. M. "Synthesis of Sugars by Aldolase-Catalyzed Condensation Reactions." J. Org. Chem. 48 (1983), 3199.
Durrwachter, J. R., Sweers, H. M., Nozaki, K., Wong, C-H., "Enzymatic Aldol Reactions/Isomerization as Route to Unusual Sugars." Tetrahedron Lett. 27:11 (1986) 1261.
Zeigler, T., Straub, A., Effenberger, F. "Enzyme-catalyzed Synthesis of 1-Deoxymannojirimycin, 1-Deoxynojirimycin, and 1,4-Dideoxy-1,4-imino-D-arabinitol." Angew. Chem. Int. Ed. Engl. 27:5 (1988) 716-717.
Durrwachter John R.
Pederson Richard L.
Wong Chi-Huey
G. D. Searle & Co.
Kovacevic Cynthia S.
Matukaitis Paul D.
Rosen Sam
Williams Roger A.
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