Perfluoro-1-azatricyclic amines as blood substitutes

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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546 93, 546 94, A61K 31445, C07D45300, C07D48708

Patent

active

046136053

ABSTRACT:
A novel compound of the formula, ##STR1## wherein k is zero or an integer of 1 to 2, j is an integer of from 1 or 3, l and m are each zero or an integer of from 1 to 3, and n is an integer of from 1 to 4, the rings A, B and C being optionally substituted with at least one trifluoromethyl group or tetrafluoroethyl group is prepared by reacting the perhydro compound corresponding thereto with fluorine. The compound is useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation.

REFERENCES:
patent: 4105798 (1978-08-01), Moore et al.
patent: 4530926 (1985-07-01), Yokoyama et al.
patent: 4535085 (1985-08-01), Yokoyama et al.

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