Preparation of functional human factor VIII in mammalian cells u

Details Preparation of functional human factor VIII in mammalian cells u Preparation of functional human factor VIII in mammalian cells u

1987-08-07

1990-10-23

Teskin, Robin L.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435320, 435 691, 4351723, 4352402, 435948, 935 32, 935 39, 935 56, 935 57, 935 70, 536 27, 530383, C12P 2100, C12N 700, C12N 1500

Patent

active

049651994

ABSTRACT:
A method for producing factor VIII in recombinant mammalian host cells utilizing an expression vector containing a selectable marker DNA and an amplifiable marker DNA. The initial selection is based upon the selectable marker and subsequent amplification of factor VIII DNA and amplifiable marker DNA is conducted in cells not deficient in the amplifiable marker.

REFERENCES:
patent: 4027013 (1977-05-01), Dick et al.
patent: 4069216 (1978-01-01), Shanbrom
patent: 4085095 (1978-04-01), Dick et al.
patent: 4093608 (1978-06-01), Iga et al.
patent: 4104266 (1978-08-01), Wickerhauser
patent: 4188318 (1980-02-01), Shanbrom
patent: 4221780 (1980-09-01), Cort
patent: 4289691 (1981-09-01), Rock et al.
patent: 4341764 (1982-07-01), Wallace et al.
patent: 4348315 (1982-09-01), Blomback et al.
patent: 4396601 (1983-08-01), Salser et al.
patent: 4399216 (1983-08-01), Axel et al.
patent: 4404131 (1983-09-01), Schwarz et al.
patent: 4757006 (1988-07-01), Toole, Jr. et al.
de Saint Vincent et al., Cell, 27:267-277, (1981).
McConlogue et al., Proc. Natl. Acad. Sci. U.S.A., 81:540-544, (1984).
Kaufman et al., Proc. Natl. Acad. Sci. U.S.A., 83:3136-3140, (1986).
Kempe et al., Cell, 9:541-550, (1976).
Wahl et al., Nature, 307:516-520, (1984).
Milbrandt et al., Molecular and Cellular Biology, 3(7):1274-1282, (1983).
Murray et al., Mol. & Cell. Biol., 3(1):32-43, (1983).
Haber & Schimke, Somatic Cell Genetics, 8(4):499-508, (1982).
Wigler et al., PNAS U.S.A., 77(6):3567-3570, (1980).
Fay, P. J. et al., "Proc. Natl. Acad. Sci. U.S.A.", 79:7200-7204, (Dec. 1982).
Fulcher, C. A. et al., "Proc. Natl. Acad. Sci. U.S.A.", 79:1648-1652, (Mar. 1982).
Knutson, G. J.+Fass, D. N., "Blood", 59(3):615-624, (Mar. 1982).
Zimmerman et al., Haemostasis and Thrombosis, Bloom et al., ed., p. 111, (1981).
Biotechnology Law Report, vol. 6, pp. 389-390, (Sep.-Oct. 1987).
Newswatch, Nov. 2, 1987, pp. 5-6, vol. 7, No. 21.
Brownlee et al., Nature, 312:307, (Nov. 1984).
Maddox, J., Nature, 312:306, (Nov. 1984).
Fulcher, C. A. et al., Proc. Natl. Acad. Sci. U.S.A., 79:1648-1652, (Mar. 1982).
Vehar, G. A. et al., Biochemistry, 19(3):401-410, (Feb. 1980).
Weinstein, M. J. et al., "Blood", 62(5):1114-1117, (Nov. 1983).
Fay et al., "Proc. Natl. Acad. Sci. U.S.A.", 79:7200-7204, (Dec. 1982).
Fay et al., "Biochimica et Biophysica Acta", 800:152-158, (1984).
Fay et al., Science, 232:995-998, (May 1986).
Fay et al., Biochimica et Biophysica Acta, 871:268-278, (1986).
Legaz, M. E. et al., "J. Biol. Chem.", 248:(11):3946-3955, (1973).
Gitschier et al., Nature, 312:326-30, (1984).
Wood et al., Nature, 312:330-37, (1984).
Vehar et al., Nature, 312:337-42, (1984).
Toole et al., Nature, 312:342-47, (1984).
Wigler et al., Cell, 16:777-785, (1979).

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