Method for potentiating and inhibiting insulin-like growth facto

Details Method for potentiating and inhibiting insulin-like growth facto Method for potentiating and inhibiting insulin-like growth facto

1995-06-07

1999-10-26

Guzo, David

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

536 235, 530380, C07K 14435

Patent

active

059731150

ABSTRACT:
Insulin-like growth factor I and II binding protein have potentiating and inhibiting activities. Cloning vectors and portable DNA sequences are disclosed.

REFERENCES:
patent: 4394443 (1983-07-01), Weissman et al.
patent: 4716112 (1987-12-01), Panayotatos
Povoa et al., "The somatomedin-binding protein isolated from a human hepatoma cell line is identical to the human aminotic fluid somatomedin-binding protein", Biochem. Biophys. Res. Comm., vol. 128, No. 3, pp. 1071-1078, May 1985.
Clemmons et al., "Cultured fibroblast monolayers secrete a protein that alters the cellular binding of somatomedin-C
sulinlike growth factor I", J. Clin. Invest., vol. 77, pp. 1548-1556, May 1986.
Drop., J. of Clinical Endocrinology and Metabolism, 59(5), 899-907 (1984).
D'Ercole, J. of Clinical Endocrinology and Metabolism, 61(4), 612-617 (1985).
Grizzard, J. of Clinical Endocrinology and Metabolism, 58(3), 535-543 (1984).
Robert S. Bar et al., "Production of IGF-Binding Proteins by Vascular Endothelial Cells," Biochemical And Biophysical Research Communications, vol. 148, No. 2, pp. 734-739 (1987).
Watson et al., "Recombinant DNA: A Short Course", W.H. Freeman and Company, New York, pp. 75-90 (1983).
Elgin et al., PNAS, USA, 84:3254-3258 (1987).
Baxter et al., BBRC, 147:403-415 (1987).
Baxter et al., BBRC, 139:1256-1261 (1986).
Mottola et al., J. Biol. Chem., 261:11180-11188 (1986).
Rutanen et al., J. Clinical Endocrinology and Metabolism, 66:173-180 (1988).
Lee et al., Molecular Endocrinology, 2:404-411 (1988).
Suggs et al., "Use of Synthetic Oligonucleotides as Hybridization Probes: Isolation of Cloned cDNA Sequences for Human .beta..sub.2 -microglobulin," Proc. Natl. Acad. Sci., USA, vol. 78, No. 11, (Nov. 1981), pp. 6613-6617.
Marston, "The Purification of Eukaryotic Polypeptides Synthesized in Escherichia coli," Biochem. J. 240, 1-12 (1986).

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