Propofol microdroplet formulations

Details Propofol microdroplet formulations Propofol microdroplet formulations

1996-03-19

1997-06-10

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

C-o-group doai

A61K 3105

Patent

active

056376251

ABSTRACT:
Formulations of phospholipid-coated microdroplets of propofol devoid of fats and triglycerides provide chronic sedation over extended periods of time without fat overload. Being free of nutrients that support bacterial growth, these microdroplet formulations are bacteriosatic and bactericidal (e.g. self-sterilizing) and thus have extended shelf life.

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patent: 4725442 (1988-02-01), Haynes
patent: 4798846 (1989-01-01), Glen et al.
King et al Anesth Analg (1992); 74:246-9 pp. 246-249 "Lidocaine for the Prevention of Pain due to Injection of Pain Due to Injection of Propofol".
Freeman Anesth Analg (1992); 74:311-9 "A Technique for Reducing Pain Associates with Propofol Administration".
Eddleston et al Intensive Care Med (1991) 17:424-426 "The effect on serum lipid concentrations . . . propofol administration".
Ewart et al Anaesthesia, (1992), vol. 47, pp. 146-148 Forum "2% Propofol for Sedation . . . ".
Dewandre et al Anaesthesia, (1994), vol. 49, pp. 8-12 "A Comparison of the 2% and 1% . . . ".
Bennett et al Postoperative Infections Traced to Contaminated Propofol vol. 333 No. 3 pp. 147-154 "Postoperative Infections . . . " (1994).
Smith et al Anesthesiology, vol. 81, No. 4, (Oct. 1994) "Propofol An Update on its Clinical Use".

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