Method for the detection of a programmed or induced cell death o

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435 6, 435 72, 435 75, G01N 3353, C12Q 168

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056374658

ABSTRACT:
The invention concerns a method for the detection of a programmed or induced cell death of eukaryotic cells as well as a suitable test kit for this method of detection.

REFERENCES:
patent: 4496654 (1985-01-01), Katz et al.
Frankfurt et al, "Flow cytometry of apoptosis and the evaluation of chemosensitivity in chronic lymphocytic leukemia and lymphoma," Proc. of the Am. Ass. for Cancer Res., vol. 34, p. 288 Mar. 1993.
Thiry et al, "Ultrastructual distribution of histones within Ehrlich tumor cell nucleoli: A Cytochemical and immunocytochemical study", J. of Histochem. and cytochem., vol. 37, No. 6, pp. 853-862 1989.
Cohen, "Programmed Cell Death in the Immune System", Adv. Immunol. 50: 55-85 (1991).
Matzinger, "The JAM test: A simple assay for DNA fragmentation and cell death", J. Immunol. Meth. 145: 185-192 (1991).
Laurent-Crawford et al. "The Cytopathic Effect of HIV is Associated with Apoptosis" Virology, vol. 185(2), pp. 829-839, issued 1991.
Harlow et al, "Antibodies:A Laboratory Manual" pp. 321,344, 555-556,583, 1988.
Naruse et al. "Antibody against single-stranded DNA detects both programmed cell death and drug-induced apoptosis" Histochemistry, vol. 101(1), pp. 73-78, issued Jan. 1994.

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