Assembly-deficient herpesvirus vaccine

Details Assembly-deficient herpesvirus vaccine Assembly-deficient herpesvirus vaccine

1996-07-26

1999-10-26

Stucker, Jeffrey

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

424 932, 4242301, 4242311, 4242291, 435236, 435325, C12N 1500, C12N 704, A01N 6300, A61K 39245

Patent

active

059726660

ABSTRACT:
A vaccine is described which comprises an assembly-deficient herpesvirus. The mutant herpesvirus is capable of infecting and undergoing DNA replication in the cells of a susceptible mammal, but is defective in capsid assembly and formation of mature virion particles. The assembly-deficient herpesvirus is avirulent and capable of generating a protective immune response in a vaccinated mammal.

REFERENCES:
patent: 5384122 (1995-01-01), Cunningham et al.
Rixon F. et al. Insertion of DNA at a unique restriction enzyme site engineered for vector purposes into the genome of herpes simplex virus type I, J. Gen. Virol. 71:2931-2939, 1990.

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