Method of identifying ligands which bind recombinant galanin rec

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 691, G01N 3353, G01N 33566

Patent

active

059726245

ABSTRACT:
This invention provides an isolated nucleic acid encoding a mammalian galanin receptor, an isolated galanin receptor protein, vectors comprising an isolated nucleic acid encoding a galanin receptor, cells comprising such vectors, antibodies directed to the galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding galanin receptors, antisense oligonucleotides complementary to unique sequences of a nucleic acid encoding a galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant galanin receptor, as well as methods of determining binding of compounds to the galanin receptor.

REFERENCES:
patent: 5290808 (1994-03-01), Sofia et al.
patent: 5436128 (1995-07-01), Harpold et al.
patent: 5436155 (1995-07-01), Bell et al.
patent: 5462856 (1995-10-01), Lerner et al.
patent: 5567714 (1996-10-01), Bruns et al.
patent: 5576296 (1996-11-01), Bartfai et al.
Marieb, E.N. (1992) Human Anatomy and Physiology, 2.sup.nd Edition, Benjamin/Cummings Publishing Company, Inc., Redwood City, California, pp. 547-551, 1992.
Ahmad, A., et al. "Identification And Molecular Cloning Of A Novel Galanin Receptor (GALR-2) In Rat Sensory Neurons" Soc. Neurosci. Abstr. (1996) 22:3 1682, Abstract 661.10.
Ahmad, S., et al. "Molecular Cloning Of A Novel Widely Distributed Galanin Receptor Subtype (GALR2)" International Association for the Study of Pain (IASP Press) (1996) Abstract No. 81: 134.
O'Donnell, D., et al. "Neuroanatomical Distribution Of A Novel Rat Galanin Receptor Subtype" Soc. Neurosci. Abstr. (1996) 22(2): 1304, Abstract 517.9.
Bouvier, M., et al. "Dynamic Palmitoylation of G-Protein-Coupled Receptors in Eukaryotic Cells" Methods in Enzymology (1995) 250: 300-314.
Parker, et al. "Cloning and Characterization of the Rat GALR1 Galanin Receptor From Rin14B Insulinoma Cells" Molecular Brain Research (1995) 34:2 179-189.
Reerk, et al. "`Homology ` In Proteins And Nucleic Acids: A Terminology Muddle And A Way Out Of It" Cell (1987) 50: 667; and.
Wallace, et al. Methods In Enzymology 152: 432-442.
Bartfai, T. et al. PNAS (USA). 90:11287-11291, (1993).
Burgevin, M.-C. et al. J. Molec. Neurosci. 6:33-41, (1995).
Chen, Y. et al. PNAS (USA). 90:3845-3849, (1993).
Deecher, D.C. et al. J. Pharmacol. Exp. Ther. 275:720-727, (1995).
Gu, Z.-F. et al. J. Pharmacol. Exp. Ther. 272:371-378, (1995).
Gustafson, E. et al. Neuroreport. 7:953-957, (1996).
Habert-Ortoli, E. et al. PNAS (USA). 91:9780-9783, (1994).
Heuillet, E. et al. Eur. J. Pharmacol. 269:139-147, (1994).
Kahl, U. and Bartfai, T. Galanin Receptors. 8(7):404-410, (1995).
Kask, K. et al. EMBO J. 15(2):236-244, (1996).
Lorimer, D.D. and Benya, R.V. Biochem. Biophys. Res. Comm. 222:379-386, (1996).
Lorinet, A.-M. et al. Eur. J. Pharmacol. 269:59-64, (1994).
Valkna, A. et al. Neurosci. Lett. 187:75-78, (1994).
Walli, R. et al. J. Mol. Endocrinol. 13:347-356, (1994).
Wynick, D. et al. PNAS (USA). 90:4231-4235, (1993).
Xu, X.-J. et al. Br. J. Pharmacol. 116:2076-2080, (1995).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method of identifying ligands which bind recombinant galanin rec does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of identifying ligands which bind recombinant galanin rec, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of identifying ligands which bind recombinant galanin rec will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-762355

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.