Hydroxyl-protecting groups attached to cytidine nucleotide compo

Details Hydroxyl-protecting groups attached to cytidine nucleotide compo Hydroxyl-protecting groups attached to cytidine nucleotide compo

1990-07-27

1995-07-04

Robinson, Douglas W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 285, 536 2851, 536 2852, C07H 19073

Patent

active

054301386

ABSTRACT:
Hydroxyl-protecting groups orthogonally removable by reduction with a liquid reducing agent are disclosed. The novel hydroxyl-protecting groups are particularly useful in the chemical synthesis of linear and branched oligonucleotide structures, as they are readily removed from the protected molecule with mild reagents such as dithionite. Examples of such hydroxyl-protecting groups include the 2-methylene-9,10-anthraquinone (Maq) carbonate ester and the p-nitrobenzyl carbonate ester.

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