Spirocyclic benzopyran imidazolines

Details Spirocyclic benzopyran imidazolines Spirocyclic benzopyran imidazolines

1994-02-10

1995-07-04

Morris, Patricia L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514402, 5483011, A61K 31415, C07D491107

Patent

active

054300487

ABSTRACT:
Spiro- [4H- 1 -benzopyran-4,4'-5'H-imidazol]-5'-ones of the Formula 1: ##STR1## wherein R.sup.1 is H, R.sup.2 F, Cl, Br, CF.sub.3, CF.sub.3 O, CN, NO.sub.2, R.sup.2 SO.sub.2, R.sup.2 NHSO.sub.2, R.sup.2 O, R.sup.2 CO, R.sup.2 OCO, or R.sup.2 NHCO. R.sup.2 is a C.sub.1 -C.sub.10 branched or linear alkyl, a C.sub.3-8 cycloalkyl, phenyl, or benzyl. X can be S, O, or NH. Both enantiomers are included in this invention as well as salts and tautomeric forms of these compounds. The subject compounds are useful in the treatment of hypertension, alopecia, and erectile dysfunction.

REFERENCES:
patent: 4740517 (1988-08-01), Kurono et al.
patent: 4874869 (1989-10-01), Ueda et al.

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