Cephalosporin derivatives

Details Cephalosporin derivatives Cephalosporin derivatives

1981-11-19

1984-02-28

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544 22, 424246, C07D50120, A61K 31545

Patent

active

044342870

ABSTRACT:
The invention concerns a process for the manufacture of 7.beta.-amino-3-cephem-3-ol-4-carboxylic acid compounds by ring closure of esters of 2-[4-(substituted-thio)-3-acylamino-2-oxoazetidin-1-yl]-3-substituted-amin o-crotonic acids and solvolyzing the enamino group in the resulting 7.beta.-acylamino-3-substituted-amino-cephem-4-carboxylic acid esters.

REFERENCES:
patent: 4013651 (1977-03-01), Spitzer
patent: 4065618 (1977-12-01), Spitzer
patent: 4110533 (1978-08-01), Woodward et al.

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