Bis-esters of 4,5-di(hydroxymethyl)-2-oxo-1,3-dioxole as antibac

Details Bis-esters of 4,5-di(hydroxymethyl)-2-oxo-1,3-dioxole as antibac Bis-esters of 4,5-di(hydroxymethyl)-2-oxo-1,3-dioxole as antibac

1982-11-15

1984-02-28

Trousof, Natalie

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

2602391, 2602452R, 549229, A61K 3143, C07D49932, C07D31740, C07D49900

Patent

active

044341733

ABSTRACT:
Derivatives of 4,5-di(hydroxymethyl)-2-oxo-1,3-dioxole in which one hydroxy group has been esterified through the carboxy group of ampicillin or amoxicillin, and the other hydroxy group has been esterified through the carboxy group of sulbactam (penicillanic acid 1,1-dioxide), are useful as antibacterial agents. Certain novel compounds, which are useful as intermediates to the aforesaid antibacterial agents, are also disclosed.

REFERENCES:
patent: 4234579 (1980-11-01), Barth
patent: 4244951 (1981-01-01), Bigham
patent: 4342693 (1982-08-01), Sakamoto et al.
patent: 4351840 (1982-09-01), Pirie
patent: 4359472 (1982-11-01), Hamanaka
patent: 4389408 (1983-06-01), Sakamoto et al.

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