Crystalline benzothiazine dioxide salts

Details Crystalline benzothiazine dioxide salts Crystalline benzothiazine dioxide salts

1982-04-13

1984-02-28

Ford, John M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544 49, C07D40112, A61K 3154

Patent

active

044341644

ABSTRACT:
The water-soluble ethylenediamine, monoethanolamine and diethanolamine salts of N-(2-pyridyl)-2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide have been prepared. These novel crystalline salts are useful in therapy as non-steroidal anti-arthritic agents. Methods for preparing these salts from the corresponding acidic starting material and the appropriate amine base are provided.

REFERENCES:
patent: 3591584 (1971-07-01), Lombardino
patent: 4116964 (1978-09-01), Zinnes et al.
patent: 4233299 (1980-11-01), Trummlitz et al.
patent: 4289879 (1981-09-01), Lombardino
J. G. Lombardino et al., "Potent Antiinflammatory N-Heterocyclic 3-Carboxamides of 4-Hydroxy-2-methyl-2H-1,2-benzothiazine 1,1-Dioxide", Journal of Medicinal Chemistry, vol. 16, No. 5, p. 493 (1973).
E. Nelson, "Solution Rate of Theophylline Salts and Effects from Oral Administration", Journal of the American Pharmaceutical Association, vol. 46, No. 10, p. 607 (1957).
A. E. Vivino, "Blood Theophylline Concentration Following the Oral Administration of Theophylline Ethylenediamine and Theophylline Isopropanolamine", Journal of the American Pharmaceutical Association, vol. 43, p. 234 (1954).

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